DocumentCode
2081727
Title
High-efficiency diffuse raman spectroscopy through a fiber bundle
Author
Matthews, T.E. ; Wax, A.
Author_Institution
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
fYear
2012
fDate
Aug. 28 2012-Sept. 1 2012
Firstpage
1181
Lastpage
1183
Abstract
Conventional spectrometers are limited in the amount of light they accept because of the requirement for narrow input apertures. A trade-off must generally be made between spectral resolution and input aperture width. This is especially a problem for performing spectroscopy on diffuse sources, such as with tissue, from which signal light has a broad spatial distribution. We introduce a method for achieving good spectral resolution from a fiber bundle input. The image of a fiber bundle has a characteristic structure. By distorting this image optically, we generate a pseudo-orthogonal intensity mask at the input of the spectrometer. The pseudo-orthogonal properties of the mask then allow decoupling at the detector plane of wavelength from spatial position. As long as the distorted image of the fiber bundle is well known, a spectrum can be recovered with spectral resolution equivalent to that of a conventional slit-based spectrometer. We demonstrate successful recovery of narrowly spaced spectral features as well as Raman spectra from a highly scattering sample with this method. This method enables probes with much higher throughputs and add fiber bundle-based spectroscopy to endoscopic designs.
Keywords
Raman spectra; biological tissues; biomedical optical imaging; cellular biophysics; endoscopes; characteristic structure; conventional slit-based spectrometer; conventional spectrometers; detector plane; diffuse sources; endoscopic designs; fiber bundle input; fiber bundle-based spectroscopy; high-efficiency diffuse Raman spectroscopy; highly scattering sample; input aperture width; narrow input apertures; optical image distortion; pseudoorthogonal intensity mask; pseudoorthogonal properties; signal light; spatial distribution; spatial position wavelength; spectral features; spectral resolution; tissue; Adaptive optics; Biomedical optical imaging; Fiber nonlinear optics; Nonlinear distortion; Optical fibers; Spectroscopy; Throughput; Image Processing, Computer-Assisted; Spectrum Analysis, Raman;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE
Conference_Location
San Diego, CA
ISSN
1557-170X
Print_ISBN
978-1-4244-4119-8
Electronic_ISBN
1557-170X
Type
conf
DOI
10.1109/EMBC.2012.6346147
Filename
6346147
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