BOGENVI: A Biomedical Ontology for Modelling Gene*Environment Interactions on Intermediate Phenotypes in Nutrigenomics Research

Author

Fabregat, Antonio ; Barrera, Elisabet ; Arregui, Maria ; Portoles, O. ; Corella, Dolores ; Coltell, Oscar

Author_Institution

Dept. of Comput. Languages & Syst., Univ. Jaume I, Castellon de la Plana

fYear

2008

fDate

17-19 June 2008

Firstpage

302

Lastpage

307

Abstract

Nutritional Genomics is demanding computing models and technological platforms in order to support acquisition, storage, management and presentation of all the information generated coming from heterogeneous sources: genotypes, environmental factors (diet and other life-style factors) and phenotypes (intermediate and final phenotypes). Our aim is to build a biomedical ontology in order to modelling gene*environment interactions on intermediate phenotypes by means of formalising and integrating genomic, environmental and phenotypic data, in the field of research on Nutritional Genomics applied to cardiovascular diseases and associated phenotypes. This ontology is part of a Health Information System based on Web engineering technologies, architectures and services, and integrating several data types to support Nutritional Genomics research in cardiovascular diseases.

Keywords

Web services; cardiovascular system; diseases; genetics; medical computing; medical information systems; ontologies (artificial intelligence); BOGENVI; Web architecture; Web engineering technology; Web service; biomedical ontology; cardiovascular disease; gene environment interaction modelling; genotype; health information system; intermediate phenotype; nutritional genomics research; Bioinformatics; Biomedical computing; Biomedical engineering; Cardiovascular diseases; Environmental factors; Environmental management; Genomics; Information systems; Ontologies; Technology management; Biomedical ontology; Gene-environment interaction; Genomic; Nutritional Genomics; Web application and services; environmental and phenotypic data integration;

fLanguage

English

Publisher

ieee

Conference_Titel

Computer-Based Medical Systems, 2008. CBMS '08. 21st IEEE International Symposium on

Conference_Location

Jyvaskyla

ISSN

1063-7125

Print_ISBN

978-0-7695-3165-6

Type

conf

DOI

10.1109/CBMS.2008.83

Filename

4562007