DocumentCode
2158112
Title
Searching Similar Modules in Protein Interaction Netwo
Author
Oka, Hiroyuki ; Arita, Masanori
Author_Institution
Grad School of Frontier Sciences, Univ of Tokyo
fYear
2005
fDate
05-08 April 2005
Firstpage
1158
Lastpage
1158
Abstract
We developed a new method to search protein networks functionally similar to a given query signal transduction pathway within protein interaction networks. This method consists of two parts: 1) a backtracking search algorithm to find topologically identical subgraphs and 2) a measurement of similarity between proteins by using Gene Ontology [1]. For validation of our method, we implemented a software tool and compared its performance with that of PathBLAST [2] on the search of MAPK signal transduction cascades [3]. The result showed that our software tool has equal or better performance than that of PathBLAST.
Keywords
Biological system modeling; Computational biology; Databases; Electronic mail; Electronics packaging; Large-scale systems; Ontologies; Organisms; Protein engineering; Software tools;
fLanguage
English
Publisher
ieee
Conference_Titel
Data Engineering Workshops, 2005. 21st International Conference on
Print_ISBN
0-7695-2657-8
Type
conf
DOI
10.1109/ICDE.2005.279
Filename
1647761
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