Probing endogenous fluorophores in cellular cancer models using temporally and spectrally resolved laser induced fluorescence

Author

Urayama, P. ; Wei Zhong ; Sloboda, R.D. ; Dragnev, K.H. ; Dmitrovsky, E. ; Mycek, M.-A.

Author_Institution

Dept. of Phys. & Astron., Dartmouth Coll., Hanover, NH, USA

fYear

2002

fDate

24-24 May 2002

Firstpage

587

Abstract

Summary from only given. Illustrates a non-invasive optical method to monitor cellular NADH and probe metabolic activity. Because the human bronchial epithelial (HBE) cells model various cancer stages, methods used here provide an understanding of the cellular contribution to tissue autofluorescence, leading possibly to optically-based methods for detecting and monitoring cancer progression and treatment.

Keywords

biological techniques; cancer; cellular biophysics; fluorescence; laser applications in medicine; molecular biophysics; HBE cells; cancer progression; cancer stages; cancer treatment; cellular NADH; cellular cancer models; endogenous fluorophores; metabolic activity; model human bronchial epithelial cells; noninvasive optical method; optically-based methods; spectrally resolved laser induced fluorescence; temporally resolved laser induced fluorescence; tissue autofluorescence; Biological system modeling; Biomedical optical imaging; Cancer; Cells (biology); Educational institutions; Fluorescence; Humans; Instruments; Optical buffering; Proteins;

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics, 2002. CLEO '02. Technical Digest. Summaries of Papers Presented at the

Conference_Location

Long Beach, CA, USA

Print_ISBN

1-55752-706-7

Type

conf

DOI

10.1109/CLEO.2002.1034358

Filename

1034358