Design and simulation of a novel bio nano actuator by prefoldin

A molecular dynamics study for characterization of Prefoldin based bio nano Actuator is presented in this paper. Prefoldin (PFD) is a hexameric molecular chaperone complex in the eukaryotic cytosol and archaea with a jellyfish-like structure containing six long coiled-coil tentacles and a large central cavity. PFDs capture protein folding intermediates or unfolded polypeptides and transfer them to group II chaperonins for facilitated folding. Each coiled coil was highly flexible, enabling it to widen its central cavity and capture various nonnative proteins. The design hypothesis and preliminary computational results of a Prefoldin based nano Actuator are presented in this paper. Our results show how archaeal PFD may be well adapted to interacting with many different substrates.