DocumentCode
2286129
Title
In silicon evaluation of nanoparticle cell interaction via human TLR3
Author
Maggi, Norbert ; Arrigo, Patrizio ; Ruggiero, Carmelina
Author_Institution
Dept. of Commun., Comput. & Syst. Sci., Univ. of Genoa, Genoa, Italy
fYear
2010
fDate
17-20 Aug. 2010
Firstpage
995
Lastpage
998
Abstract
Nanomaterials are becoming widely used in nanomedicine for pharmaceutical applications. This paper addresses the analysis of the possible cytotoxic effects of nanostructured materials. Specifically, the behavior of some nanoparticles against Toll-like receptors (TLRs), a class of proteins that play a key role in the innate immune system, is considered by docking analysis. The results show that the nanoparticles that have been considered have the potential to affect the immune system via TLRs.
Keywords
biomedical materials; cellular biophysics; drugs; nanomedicine; nanoparticles; proteins; toxicology; Toll-like receptors; cytotoxic effects; docking analysis; human TLR3; nanomaterials; nanomedicine; nanoparticle cell interaction; nanostructured materials; pharmaceuticals;
fLanguage
English
Publisher
ieee
Conference_Titel
Nanotechnology (IEEE-NANO), 2010 10th IEEE Conference on
Conference_Location
Seoul
ISSN
1944-9399
Print_ISBN
978-1-4244-7033-4
Electronic_ISBN
1944-9399
Type
conf
DOI
10.1109/NANO.2010.5697852
Filename
5697852
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