Multi-rate estimation and monitoring of process variables in a bioreactor

This paper addresses the problem of simultaneous state and parameter estimation for a bioprocess. It proposes a formal approach to incorporate multiple rates of sampling, that typically exist in a bioprocess, so that estimation is done using all of and the most up to-date measurements. The software sensor that results from the above approach is validated using experimental data from fed-batch fermentation of Streptomyces Clavuligerus