Modeling and inversion of weakly scattering subcellular inhomogeneities in electrically large cells

In this paper, a novel ODT technique for imaging weakly scattering sub-cellular structures is proposed. The method is tested with FDTD simulations for various cell models. Remarkably accurate reconstructions are obtained for cells with a diameter less than 80lambda and residing in a matched background. Qualitative and quantitative superiority of the proposed method to the conventional ODT techniques is demonstrated for the investigated cases. Quality of the reconstructions are observed to deteriorate with increasing frequency and background-object contrast.