Noise suppression of fluorescein angiogram sequences using bilateral filter

In this paper, a relatively flexible filter called extended bilateral filter is proposed, by which some particular filters can be designed via selecting an appropriate pixel of interest (POI) and defining a kernel for the filter according to some specified requirements. Based on the filter, a fluorescein-angiogram-oriented filter, high-intensity preserving (HIP) filter is introduced to solve the problems of high-intensity preservation when denoising. The results of the experiments show that the HIP filter has the ability of noise suppression, and the ability of high-intensity preservation, which can keep the intensities of bright pixels from degrading via distributing the weights adaptively according to the location and the intensity of each pixel.