DocumentCode
2378032
Title
Temporal logics for phylogenetic analysis via model checking
Author
Blanco, Roberto ; de Miguel Casado, Gregorio ; Requeno, José Ignacio ; Colom, José Manuel
Author_Institution
Dept. of Comput. Sci. & Syst. Eng. (DIIS), Univ. de Zaragoza, Zaragoza, Spain
fYear
2010
fDate
18-18 Dec. 2010
Firstpage
152
Lastpage
157
Abstract
The need for general-purpose algorithms for the study of biological properties in phylogenetics motivates the research in formal verification frameworks so that researchers can focus their efforts exclusively on evolution modelling and property specification. To this end, model checking, a mature automated verification technique from computer science, is proposed for phylogenetic analysis. Three cornerstones found our approach: modelling evolution dynamics with transition systems; specifying phylogenetic properties using temporal logic formulae; and verifying the latter by means of automated computer tools. As prominent advantages stemming of studying phylogenetic properties with this approach, different models of evolution can be considered, complex properties can be specified as the logical composition of others, and the refinement of unfulfilled properties as well as the discovery of new ones can be undertaken by exploiting the verification results.
Keywords
DNA; bioinformatics; data analysis; evolution (biological); genetics; genomics; molecular biophysics; temporal logic; DNA sequence; automated verification technique; data analysis; evolution dynamics; general-purpose algorithm; phylogenetic analysis; temporal logic formulae; formal verification; model checking; phylogenetic analysis; temporal logic;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedicine Workshops (BIBMW), 2010 IEEE International Conference on
Conference_Location
Hong, Kong
Print_ISBN
978-1-4244-8303-7
Electronic_ISBN
978-1-4244-8304-4
Type
conf
DOI
10.1109/BIBMW.2010.5703790
Filename
5703790
Link To Document