• DocumentCode
    2378032
  • Title

    Temporal logics for phylogenetic analysis via model checking

  • Author

    Blanco, Roberto ; de Miguel Casado, Gregorio ; Requeno, José Ignacio ; Colom, José Manuel

  • Author_Institution
    Dept. of Comput. Sci. & Syst. Eng. (DIIS), Univ. de Zaragoza, Zaragoza, Spain
  • fYear
    2010
  • fDate
    18-18 Dec. 2010
  • Firstpage
    152
  • Lastpage
    157
  • Abstract
    The need for general-purpose algorithms for the study of biological properties in phylogenetics motivates the research in formal verification frameworks so that researchers can focus their efforts exclusively on evolution modelling and property specification. To this end, model checking, a mature automated verification technique from computer science, is proposed for phylogenetic analysis. Three cornerstones found our approach: modelling evolution dynamics with transition systems; specifying phylogenetic properties using temporal logic formulae; and verifying the latter by means of automated computer tools. As prominent advantages stemming of studying phylogenetic properties with this approach, different models of evolution can be considered, complex properties can be specified as the logical composition of others, and the refinement of unfulfilled properties as well as the discovery of new ones can be undertaken by exploiting the verification results.
  • Keywords
    DNA; bioinformatics; data analysis; evolution (biological); genetics; genomics; molecular biophysics; temporal logic; DNA sequence; automated verification technique; data analysis; evolution dynamics; general-purpose algorithm; phylogenetic analysis; temporal logic formulae; formal verification; model checking; phylogenetic analysis; temporal logic;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Bioinformatics and Biomedicine Workshops (BIBMW), 2010 IEEE International Conference on
  • Conference_Location
    Hong, Kong
  • Print_ISBN
    978-1-4244-8303-7
  • Electronic_ISBN
    978-1-4244-8304-4
  • Type

    conf

  • DOI
    10.1109/BIBMW.2010.5703790
  • Filename
    5703790