Multi-scale modeling of excitation-contraction coupling in the normal and failing heart

Author

Kerckhoffs, Roy C P ; Campbell, Stuart G. ; Flaim, Sarah N. ; Howard, Elliot J. ; Sierra-Aguado, Jazmin ; Mulligan, L.J. ; McCulloch, Andrew D.

Author_Institution

Dept of Bioeng., Univ. of California San Diego, La Jolla, CA, USA

fYear

2009

fDate

3-6 Sept. 2009

Firstpage

4281

Lastpage

4282

Abstract

Here we describe new computational models of cardiac electromechanics starting from the cellular scale and building to the tissue, organ and system scales. We summarize application to human genetic diseases (LQT1 and LQT3) and to modeling of congestive heart failure.

Keywords

bioelectric phenomena; biological organs; biological tissues; biomechanics; cardiology; cellular biophysics; diseases; electromechanical effects; genetics; physiological models; cardiac electromechanics; cellular scale; computational model; congestive heart failure modeling; excitation-contraction coupling; heart failure model; human genetic diseases; multiscale modeling; organ scales; tissue scales; Algorithms; Computer Simulation; Electrophysiology; Equipment Design; Heart; Heart Conduction System; Heart Failure; Humans; Long QT Syndrome; Models, Cardiovascular; Models, Genetic; Muscle Cells; Mutation; Myocardial Contraction; Software;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Conference_Location

Minneapolis, MN

ISSN

1557-170X

Print_ISBN

978-1-4244-3296-7

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2009.5332708

Filename

5332708