Mathematical modeling of triamcinolone acetonide drug release from the i-vation™ intravitreal implant (a controlled release platform)

Author

Barnett, Peter J.

fYear

2009

fDate

3-6 Sept. 2009

Firstpage

3087

Lastpage

3090

Abstract

In-vitro drug release of triamcinolone acetonide from the I-vationtrade implant can be controlled and tuned by varying its formulation ingredients. These release characteristics can be modeled using a parabolic partial differential equation to describe one dimensional Fickian drug diffusion in a durable polymer matrix.

Keywords

biodiffusion; drug delivery systems; parabolic equations; partial differential equations; polymer blends; I-vation intravitreal implant; controlled drug release platform; durable polymer matrix; formulation ingredients; mathematical modeling; one dimensional Fickian drug diffusion; parabolic partial differential equation; triamcinolone acetonide drug release; Anti-Inflammatory Agents; Chemistry, Pharmaceutical; Computer Simulation; Drug Delivery Systems; Drug Design; Equipment Design; Eye Infections, Bacterial; Humans; Hydrogen-Ion Concentration; Models, Theoretical; Polymers; Technology, Pharmaceutical; Time Factors; Triamcinolone Acetonide; Vitreous Body;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Conference_Location

Minneapolis, MN

ISSN

1557-170X

Print_ISBN

978-1-4244-3296-7

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2009.5332803

Filename

5332803