Modelling heart beat initiation and propagation using the MML framework

Author

Chang, David ; Dokos, Socrates ; Lovell, Nigel H.

Author_Institution

Grad. Sch. of Biomed. Eng., Univ. of New South Wales, Sydney, NSW, Australia

fYear

2009

fDate

3-6 Sept. 2009

Firstpage

4495

Lastpage

4498

Abstract

The modeling markup language (MML) framework provides a temporo-spatial level modeling tool, consisting of two representation languages with tools which utilize CellML, a mathematical biological model representational language. The purpose of MML is to encourage reuse, sharing and efficiency. In this study, we utilize MML to investigate the role of the hyperpolarizing activated (i_f) current of the sinoatrial node (SAN), the natural pacemaker of the heart. The i_f is believed to play an important role in heart automaticity and pacing rate. By using the MML framework and CellML specification, we construct a range of models to examine the role of i_f in the SAN as well as aspects of wavefront propagation from the SAN into the atria.

Keywords

bioelectric phenomena; cardiology; medical diagnostic computing; physiological models; CellML; atria; heart automaticity; heart beat; hyperpolarization; modeling markup language; natural pacemaker; pacing rate; sinoatrial node; temporo-spatial level modeling; Computational Biology; Databases, Factual; Heart Rate; Models, Cardiovascular; Models, Statistical; Sinoatrial Node;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Conference_Location

Minneapolis, MN

ISSN

1557-170X

Print_ISBN

978-1-4244-3296-7

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2009.5333683

Filename

5333683