Modeling of the cell membrane response to ultra short electric pulses

This paper discusses the dynamics aspects of pore formation in the cell membrane submitted to ultra short electric pulses. The transient transmembrane potential (TMP) is calculated using an analytical approximation, which is subsequently coupled to the Smoluchowski equation to assess the dynamics of pore generation. Alternatively, the finite element method is also considered for the TMP calculation. The formulation is employed to calculate the pore formation, growth and size evolution in double shell cells of different shapes.