Engineering NIR dyes for fluorescent lifetime contrast

Author

Berezin, Mikhail Y. ; Lee, Hyeran ; Akers, Walter ; Guo, Kevin ; Goiffon, Reece J. ; Almutairi, Adah ; Fréchet, Jean M J ; Achilefu, Samuel

Author_Institution

Sch. of Med., Dept. of Radiol., Washington Univ., St. Louis, MO, USA

fYear

2009

fDate

3-6 Sept. 2009

Firstpage

114

Lastpage

117

Abstract

The excited state of an organic molecule is a crossroads which can lead to many directions, such as non-radiative emission as heat, fluorescence, intersystem crossing and phosphorescence. Due to the unpredictable nature of the excited molecular structure, manipulation of this represents significant challenges for physicists and chemists. However, the successful management of the excited state provides a number of benefits with innumerable applications to fields like photonics and medicine. One such property of the excited state with powerful ramifications in medical diagnostics is fluorescence lifetime.

Keywords

biodegradable materials; biomedical optical imaging; dyes; excited states; fluorescence; radiative lifetimes; NIR dyes; biodegradable dendrimer; fluorescence lifetime imaging; fluorescent lifetime contrast; medical diagnostics; molecular structure; organic molecule excited state; Animals; Contrast Media; Drug Design; Fluorescent Dyes; Image Enhancement; Kinetics; Mice; Microscopy, Fluorescence; Spectroscopy, Near-Infrared; Time Factors; Whole Body Imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Conference_Location

Minneapolis, MN

ISSN

1557-170X

Print_ISBN

978-1-4244-3296-7

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2009.5334834

Filename

5334834