The Transmembrane Potential Induced on a Permeabilized Cell in SuspensionsExposed to DC Pulse Fields

During the electroporation, the membrane conductivity increase dramatically. The transmembrane potential (TMP) on the permeabilize cells in suspensions exposed to a DC pulse field, is theoretically a complex problem especially due to the rotation and the mutual interactions among the permeabilize cells. Based on the Maxwell equivalent theory, an analytical solution for the TMP on the permeabilize cells was derived in this paper. The equation shows that the TMP depends on parameters such as the external electric field, critical angle of electroporation, cell radio, conductivity of the cytoplasm, membrane and external medium, cell arrangement and cell volume fraction.