The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research

Author

Tass, Peter A. ; Qin, Li ; Hauptmann, Christian ; Dovero, Sandra ; Bezard, Erwan ; Boraud, Thomas ; Meissner, Wassilios G.

Author_Institution

Institute of Neuroscience and Medicine-Neuromodulation, Research Centre Juelich, Germany and the Division for Neuromodulation, Medical School, University of Cologne, Germany

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

663

Lastpage

666

Abstract

Deep brain stimulation (DBS) has been applied in more than 70000 patients worldwide during the last two decades. The main target is the subthalamic nucleus (STN) for the treatment of motor complications in late stage Parkinson´s disease (PD). Positive results in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated non-human primates have set the grounds for its successful translation to PD patients. Since then, this model has allowed gaining significant insights in the underlying mechanisms of action of DBS and is currently being used for the development of new stimulation techniques. Altogether, this underpins the high potential of this preclinical model for future translation of DBS research in PD.

Keywords

Basal ganglia; Brain stimulation; Humans; Neurons; Neuroscience; Parkinson´s disease; Satellite broadcasting; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Deep Brain Stimulation; Disease Models, Animal; Humans; Parkinsonian Disorders; Primates; Translational Medical Research;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6090148

Filename

6090148