Parameter exploration of staircase-shape extracellular stimulation for targeted stimulation of myelinated axon

Author

Ueno, Ayako ; Karashima, Akihiro ; Nakao, Mitsuyuki ; Katayama, Norihiro

Author_Institution

Biomodeling Laboratory, Department of Applied Information Sciences, Graduate School of Information Sciences, Tohoku University, Sendai, Japan

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

912

Lastpage

915

Abstract

Spatio-temporal dynamics of a mathematical model of myelinated axon in response to staircase-shape extracellular electrical stimulation, which was developed for selective nerve stimulation, is investigated by the computer simulation. It is shown that the response is classified into four types: subthreshold response, cathodic excitation, anodal block and anodal break excitation. Based on the simulation results, simple diagrams representing the response characteristics of the axon are constructed as functions of stimulation parameters and distance between the axon and electrode. The diagram would be useful for determining simulation parameters for dynamic targeted stimulation of myelinated axon.

Keywords

Arrays; Biomembranes; Electric potential; Electrodes; Extracellular; Mathematical model; Nerve fibers; Action Potentials; Animals; Computer Simulation; Electric Stimulation; Humans; Membrane Potentials; Models, Neurological; Nerve Fibers, Myelinated; Neural Conduction;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6090204

Filename

6090204