Effects of bile acids and derivatives on blood lipid level of ApoE single-knockout mice

In addition to be the major metabolites of cholesterol, bile acids are also served as key regulators for nuclear receptors LXR, FXR, PXR and VDR and maintain blood lipid homostasis. Objective: to study the oral effects of bile acids and derivatives on blood lipids of ApoE gene single-knockout mice. Methods: Using ApoE gene single-knockout mice as experimental subjects, bile acids and derivatives were used as experimental medicine to find out the regulation of nuclear receptors on blood lipid concentration. Results: Total serum cholesterol and triglycerides increased in cholic Acid (600mg/kg/d) and hyodeoxycholic Acid (600mg/kg/d) treatment group; total cholesterol raised by LXR agonists hyodeoxycholic acid dimethyl Amide (200mg/kg/d) and Gynostemma pentaphyllum extract derivative (200mg/kg/d); triglycerides decreased in FXR agonist dehydroxycholic Acid group (200mg/kg/d). Conclusion: hyodeoxycholic acid does not suppress hepatic bile acid synthesis. This study provides positive evidence for treatment of hyperlipidemia using bile acid derivatives.