Protective effect of ginsenoside Rg1 on acute myocardial ischemia in Guinea pigs

Author

Lai, FangYuan ; Chen, MinLi

Author_Institution

Coll. of 2nd Clinical Med., Zhejiang Chinese Med. Univ., Hangzhou, China

fYear

2011

fDate

24-26 June 2011

Firstpage

7014

Lastpage

7017

Abstract

Objective: To observe the protective effect of Rg1 on acute myocardial ischemia in Guinea pigs. Methods: Acute myocardial ischemia models were induced by pituitrin, the effect of Ginsenoside Rg1 on ECG in acute myocardial ischemia Guinea pigs was observed, and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine phosphokinase (CK), lactate dehydrogenase (LDH), superoxide dismutase (SOD), glutathion peroxidase (GSH-Px) activities and malondialdehyde (MDA) content were detected. Results: Ginsenoside Rgl could reduce the heights of ST segment and T wave which caused by injecting pituitrin (P<;0.05), and resist the reduce of heart rate and prolong of PR interval, QRS wave group and QT interval, and it also inhibited the levels of serum AST, CK and LDH (P<;0.05, P<;0.01), increased the activities of serum SOD and GSH-Px, decreased MDA content (P<;0.05, P<;0.01). Conclusion: Ginsenoside Rg1 have the functions of anti acute myocardium ischemia.

Keywords

biochemistry; blood vessels; cardiovascular system; diseases; electrocardiography; haemodynamics; molecular biophysics; organic compounds; patient treatment; ECG; Guinea pigs; ST segment; T-wave; acute myocardial ischemia; aspartate aminotransferase; creatine phosphokinase; ginsenoside Rg1; glutathion peroxidase; heart rate; lactate dehydrogenase; malondialdehyde; pituitrin; protective effect; serum alanine aminotransferase; superoxide dismutase; Analysis of variance; Diseases; Electronic mail; Heart rate; Myocardium; Publishing; Stress; Ginsenoside Rg1; Guinea pig; Myocardial ischemia; antioxidant;

fLanguage

English

Publisher

ieee

Conference_Titel

Remote Sensing, Environment and Transportation Engineering (RSETE), 2011 International Conference on

Conference_Location

Nanjing

Print_ISBN

978-1-4244-9172-8

Type

conf

DOI

10.1109/RSETE.2011.5965979

Filename

5965979