Measuring, modeling and manipulating cell communication in Drosophila egg development

Author

Muratov, Cyrill B.

Volume

3

fYear

2002

fDate

23-26 Oct. 2002

Firstpage

2200

Abstract

We report a model-based analysis of a recently proposed mechanism in Drosophila oogenesis (Peri et al., 1999; Sapir et al., 1998; Wasserman and Freeman, 1998). Our model describes the spatial organization and the dynamics of autocrine and paracrine signaling through the Drosophila Epidermal Growth Factor Receptor (EGFR) (Casci and Freeman, 1999; Nilson and Schupbach, 1999; Perrimon and Perkins, 1997; Schweitzer and Shilo, 1997). We use the model to estimate the relative spatial ranges and time scales of the relevant feedback loops, to interpret the phenotypic transitions in eggshell morphology, and to predict the effects of new genetic manipulations.

Keywords

cellular transport; feedback; genetics; physiological models; Drosophila egg development; Drosophila epidermal growth factor receptor; autocrine signaling; eggshell morphology; feedback loops; fruit flies; genetic manipulations; model-based analysis; paracrine signaling; phenotypic transitions interpretation; relative spatial ranges; time scales; Amino acids; Embryo; Epidermis; Feedback loop; Genetics; Inhibitors; Pattern analysis; Predictive models; Proteins; Signal analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1053239

Filename

1053239