Variability of tissue optical properties in cancer patients receiving photodynamic therapy

Author

Jacques, S.L. ; Bargo, P. ; Goodell, T. ; Sleven, R. ; Kovall, G. ; Blair, G.

Author_Institution

Providence St. Vincent Med. Center, OR, USA

Volume

3

fYear

2002

fDate

23-26 Oct. 2002

Firstpage

2283

Abstract

Photodynamic Therapy (PDT) uses light to activate photosensitive drug to yield oxidative injury to targeted tissues such as cancer. The ability of treatment light to penetrate a tissue and activate the drug that has accumulated in a target tissue depends on the tissue optical properties, especially the blood perfusion. An endoscopic spectroscopic probe was developed for monitoring esophageal and lung tissues and tested in patients in a pilot clinical study.

Keywords

biological tissues; cancer; endoscopes; haemorheology; lung; oxidation; photodynamic therapy; probes; blood perfusion; cancer patients receiving photodynamic therapy; drug activation; endoscopic spectroscopic probe; esophageal tissues; lung tissues; photosensitizive drug activation; pilot clinical study; targeted tissues; tissue optical properties variability; Blood; Cancer; Drugs; Esophagus; Injuries; Lungs; Medical treatment; Patient monitoring; Probes; Spectroscopy;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1053283

Filename

1053283