An Alternative Lidocaine Hydrochloride Liposomal Gel Formulation : Preparation, Percutaneous Permeation and Release Kinetics

Author

Zhang, Xue-nong ; Gong, Jin-Hong ; Liu, Yang ; Tang, Li-Hua ; Xu, Xiao-jun

Author_Institution

Coll. of Pharmacy, Soochow Univ., Suzhou, China

fYear

2009

fDate

11-13 June 2009

Firstpage

1

Lastpage

4

Abstract

Liposomal hydrogel formulations of lidocaine hydrochloride(LDH)have been prepared and drug percutaneous permeation and release properties in vitro have been evaluated. An optimal hydrogel prescription with carbopol as base involved permeation enhancers as polyethylene glycol (PEG-400), Azone, poloxamer and propylene glycol was screened in vitro. Percutaneous permeation kinetic models of LDH in three formulations: liposome solution, conventional gel and liposomal gel were studied.

Keywords

drugs; hydrogels; materials preparation; permeability; skin; Azone; LDH; PEG-400; carbopol; drug release kinetics; lidocaine hydrochloride liposomal gel formulation; optimal hydrogel prescription; percutaneous permeation kinetic models; poloxamer; polyethylene glycol; propylene glycol; transdermal therapeutic system; Anesthetic drugs; Biomembranes; Diseases; Drug delivery; In vitro; Kinetic theory; Lipidomics; Pharmaceuticals; Skin; Speech synthesis;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on

Conference_Location

Beijing

Print_ISBN

978-1-4244-2901-1

Electronic_ISBN

978-1-4244-2902-8

Type

conf

DOI

10.1109/ICBBE.2009.5162308

Filename

5162308