MR measurements of Gd-DTPA kinetics for estimation of myocardial perfusion

Author

Machnig, Th ; Wilke, N. ; Engels, G. ; Bachmann, K. ; Simm, F.C. ; Ellermann, J. ; Zhang, J. ; Ya, X. ; Merkel, H. ; Path, G. ; Bache, R.J. ; Ugurbil, K.

Author_Institution

Med. Klinik, Erlangen Univ., Germany

fYear

1991

fDate

23-26 Sep 1991

Firstpage

5

Lastpage

8

Abstract

By administering gadolinium-diethylenetriamine-penta-acetic acid (Gd-DTPA) in conjunction with the Turbo-Flash sequence, the authors assessed the potential of dynamic contrast-enhanced ultrafast magnetic resonance imaging (MRI) to detect and quantify reductions in myocardial perfusion secondary to stenosis and hyperemia induced by Dipyridamole. In ten subjects and three dogs signal intensity-time curves were generated in regions of interest over myocardium. A one-compartment model was introduced to describe the kinetics of Gd-DTPA. The first results indicate that measurements of Gd-DPTA kinetics seem of potential value for the non-invasive assessment of myocardial perfusion

Keywords

biomedical NMR; biomedical measurement; blood; cardiology; muscle; 1-compartment model; Dipyridamole; Gd-DTPA kinetics; MR measurements; Turbo-Flash sequence; contrast-enhanced ultrafast magnetic resonance imaging; dogs; gadolinium-diethylenetriamine-penta-acetic acid; hyperemia; magnetic resonance measurement; myocardial perfusion estimation; noninvasive assessment; region of interest; signal intensity-time curves; stenosis; Animals; Arteries; Biomedical engineering; Biomedical imaging; Catheters; Dogs; Kinetic theory; Monitoring; Myocardium; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 1991, Proceedings.

Conference_Location

Venice

Print_ISBN

0-8186-2485-X

Type

conf

DOI

10.1109/CIC.1991.169031

Filename

169031