Preparation of Calcium Phosphate-Based Bone Repair Materials

We developed a calcium phosphate cement that could be molded into any desired shape due to its chewing-gum-like consistency after mixing. The powder component of the cement consists of tricalcium phosphate (TCP). The liquid component consists of chitosan, citric acid and glucose solution. In this study, we used four groups of cement to investigate the mechanical properties and biocompatibility of the new biomaterial in vivo. The setting times of the cements were 5-30 min. X-ray diffraction analysis showed that the products were hydroxyapatite (HA) and dicalcium phosphate anhydrous. When the concentration of citric acid was increased, the compressive strength of specimen increased. The animal experiments showed that the material was nontoxic and osteoinductivity.