Prediction of shear stress distribution throughout 3D bone scaffold in perfusion environment

In tissue engineering, mechanical stimuli play an important role in the cell proliferation process. This paper developed a 3D model to analyze the shear stress distribution in porous scaffold dynamically. A series of 3D scaffolds with different porosity level (60%~80%) were constructed to generate a large amount of shear stress distributions in the CFD tool. The simulations revealed that average shear stress is linear with velocity and the porosity has a strong influence of average shear stress. A linear prediction model is built on the analyzing data, which can demonstrate relationships between shear stress distribution on the inter surface of the 3D scaffold and the perfusion conditions.