A 3-D capillary-endothelium-mimetic microfluidic chip for studying the extravasation behaviour of neutrophils

Author

Punde, Tushar H. ; Wu, Wen-Hao ; Shih, Po-Chen ; Fu, Chien-Yu ; Wang, Tsung-Pao ; Hsu, Long ; Chang, Hawn-You ; Liu, Cheng-Hsien

Author_Institution

Inst. of NanoEngineering & Microsyst., Hsinchu, Taiwan

fYear

2011

fDate

5-9 June 2011

Firstpage

2251

Lastpage

2254

Abstract

Inflammation is a fundamental biology problem with daily threats to human health. In early inflammatory stage, the most important cell type involved is neutrophil, which represents the most massive leukocyte population. In this paper, we report a 3D reusable microfluidic chip which mimics the capillary endothelial lining and we have made an attempt to imitate the hemodynamic-factor in order to study the extravasation behavior of neutrophils. This microsystem is a continuous flow system which mimics the dynamic, three dimensional micro environment in the blood vessel.

Keywords

biomimetics; blood vessels; capillarity; cellular biophysics; haemodynamics; lab-on-a-chip; microfluidics; 3-D capillary-endothelium-mimetic microfluidic chip; 3D reusable microfluidic chip; blood vessel; capillary endothelial lining; cell type; continuous flow system; early inflammatory stage; extravasation behaviour; fundamental biology problem; hemodynamic factor; human health; inflammation; massive leukocyte population; neutrophils; three dimensional micro environment; Adhesives; Arrays; Blood; Etching; Microfluidics; Silicon; Biomimetics; Chemotaxis; Microfluidics; Neutrophil extravasation;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International

Conference_Location

Beijing

ISSN

Pending

Print_ISBN

978-1-4577-0157-3

Type

conf

DOI

10.1109/TRANSDUCERS.2011.5969361

Filename

5969361