CMOS microelectrode array for bidirectional interaction with neuronal networks

Author

Heer, F. ; Hafizovic, S. ; Franks, W. ; Ugniwenko, T. ; Blau, A. ; Ziegler, C. ; Hierlemann, A.

Author_Institution

PEL, Zurich, Switzerland

fYear

2005

fDate

12-16 Sept. 2005

Firstpage

335

Lastpage

338

Abstract

We report on a microelectrode array for bidirectional communication (stimulation and recording) with electrogenic cells, for e.g., observing neuronal information processing in vitro. The chip overcomes the interconnect challenge that limits today´s bidirectional microelectrode arrays. The array has been fabricated in industrial CMOS-technology with post-CMOS processing and comprises all necessary control circuitry and on-chip A/D-conversion. Measurements from neural cell cultures with amplitudes of 500 μV are presented.

Keywords

CMOS integrated circuits; analogue-digital conversion; bioelectric potentials; medical signal processing; microelectrodes; 500 muV; CMOS technology; bidirectional communication; bidirectional interaction; electrogenic cells; microelectrode array; neural cell culture; neuronal information processing; neuronal networks; on-chip A/D conversion; post-CMOS processing; Bidirectional control; Biological neural networks; Communication system control; In vitro; Industrial control; Information processing; Integrated circuit interconnections; Microelectrodes; Semiconductor device measurement; Textile industry;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Circuits Conference, 2005. ESSCIRC 2005. Proceedings of the 31st European

Print_ISBN

0-7803-9205-1

Type

conf

DOI

10.1109/ESSCIR.2005.1541628

Filename

1541628