Trust based decision making approach for protein ontology

Biomedical knowledge of proteomics domain is represented in the protein ontology, whose instantiations, which are undergoing evolution, need a good management and maintenance system. Protein ontology instantiations signify information about proteins that is shared and has evolved to reflect development in protein ontology project and proteomics domain itself. In this paper we explore the development of a conceptual framework for protein ontology instantiations management by using the concepts of trust and reputation in biomedical domain. The developed and engineered ontology approach is trustworthy and facilitates reliable additions and updates to the protein ontology.