Simulation of the therapeutic region during HIFU therapy

Author

Xiaorui, Chen ; Xiaojing, Zhang ; Shaolin, Wang ; Xiqi, Jian

Author_Institution

Sch. of Biomed. Eng., Tianjin Med. Univ., Tianjin, China

Volume

2

fYear

2011

fDate

15-17 Oct. 2011

Firstpage

986

Lastpage

989

Abstract

Prediction of the size, shape, and variation of the therapeutic region (TR) induced by HIFU has a great significance to HIFU treatment planning. In this study, the approximation of Westervelt formula for the nonlinear propagation of ultrasound and Pennes bio-heat transfer equation have been used along with the Finite Difference Time Domain (FDTD) method to calculate the temperature field. Then the therapeutic region based on the temperature distribution was analyzed. It was found that an increase of the exposure time and the TR temperature resulted in the appearance of the influence of tissue acoustic properties. It was also found that during the process of obtaining the same lesion size, the average input intensity and the exposure time express a certain relationship.

Keywords

biological tissues; biomedical ultrasonics; finite difference time-domain analysis; heat transfer; hyperthermia; radiation therapy; temperature distribution; transfer functions; ultrasonic focusing; ultrasonic propagation; ultrasonic therapy; HIFU therapy; Pennes bio-heat transfer equation; Westervelt formula; average input intensity; finite difference time domain method; high intensity focused ultrasound; lesion size; nonlinear ultrasound propagation; temperature distribution; temperature field; tissue acoustic properties; Acoustics; Mathematical model; Numerical models; Temperature distribution; Temperature measurement; Ultrasonic imaging; FDTD; HIFU; acoustic properties; therapeutic region;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering and Informatics (BMEI), 2011 4th International Conference on

Conference_Location

Shanghai

Print_ISBN

978-1-4244-9351-7

Type

conf

DOI

10.1109/BMEI.2011.6098400

Filename

6098400