Application of nanobiotechnology to construct a piezoelectric sensor matrix sensing the flexibility of immunoglobulin

Author

Huang, G.S. ; Chen, Yu-Shiun ; Lin, Xin-Yau

Author_Institution

Instititute of Nanotechnol., Nat. Chiao Tung Univ., Hsinchu

fYear

2007

fDate

2-5 Aug. 2007

Firstpage

7

Lastpage

10

Abstract

We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.

Keywords

biosensors; coatings; gold; macromolecules; molecular biophysics; nanobiotechnology; nanoparticles; piezoelectric devices; SiO₂-Au; antiserum; biological macromolecule; biosensor sensing; gold nanoparticles; immunoglobulin; nanobiotechnology; piezoelectric sensor matrix; quartz crystal microbalance; size 12 nm; size 3.5 nm; size 37 nm; size 5 nm; Biosensors; Chemistry; Economic indicators; Electrodes; Frequency; Gold; Immune system; Nanobiotechnology; Nanoparticles; Nanotechnology; Biosensor; Flexibility; Immunoglobulin; Matrix; Quartz Crystal Microbalance;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanotechnology, 2007. IEEE-NANO 2007. 7th IEEE Conference on

Conference_Location

Hong Kong

Print_ISBN

978-1-4244-0607-4

Electronic_ISBN

978-1-4244-0608-1

Type

conf

DOI

10.1109/NANO.2007.4601129

Filename

4601129