Modeling microvascular networks

Author

Frasch, H. Frederick ; Kresh, J. Yasha ; Noordergraaf, Abraham

Author_Institution

Dept. of Bioeng., Pennsylvania Univ., Philadelphia, PA, USA

fYear

1991

fDate

4-5 Apr 1991

Firstpage

185

Lastpage

186

Abstract

The authors describe preliminary results from a 55-branch distributed model of a microvascular network. Linearized equations of motion and continuity for each branch were solved simultaneously to generate the input impedance of the model. Effects of dimensional (length, radii) and structural variations of the network were investigated. The input impedance is insensitive to physiologically reasonable variations of these parameters. The form of the input impedance suggests that the network may be reduced to a three-element Windkessel if global relationships, rather than local perfusion or exchange phenomena, are of interest

Keywords

physiological models; 3-element Windkessel; 55-branch distributed model; dimensional variations; equations of motion; exchange phenomena; global relationships; input impedance; local perfusion; microvascular networks modeling; structural variations; Density measurement; Displays; Impedance; Linear systems; Muscles; Network topology; Red blood cells; Solid modeling; Statistical distributions; Viscosity;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1991., Proceedings of the 1991 IEEE Seventeenth Annual Northeast

Conference_Location

Hartford, CT

Print_ISBN

0-7803-0030-0

Type

conf

DOI

10.1109/NEBC.1991.154638

Filename

154638