A wireless slanted optrode array with integrated micro leds for optogenetics

This paper presents a wireless-enabled, flexible optrode array with multichannel micro light-emitting diodes (μ-LEDs) for bi-directional wireless neural interface. The array integrates wirelessly addressable μ-LED chips with a slanted polymer optrode array for precise light delivery and neural recording at multiple cortical layers simultaneously. A droplet backside exposure (DBE) method was developed to monolithically fabricate varying-length optrodes on a single polymer platform. In vivo tests in rat brains demonstrated that the μ-LEDs were inductively powered and controlled using a wireless switched-capacitor stimulator (SCS), and light-induced neural activity was recorded with the optrode array concurrently.