Nanosecond rise time minipulser for cell electroperturbation

Author

Gu, Xianyue ; Wijetunga, Panduka ; Kuthi, Andras ; Behrend, Matthew ; Vernier, P. Thomas ; Gundersen, Martin A.

Author_Institution

Dept. of Electr. Eng., Southern California Univ., Los Angeles, CA, USA

Volume

2

fYear

2003

fDate

15-18 June 2003

Firstpage

943

Abstract

The design of a compact pulse generator with sub-ns rise time for the study of short pulse cell electroperturbation is presented. The generator is based on a small, water dielectric Blumlein PFN (pulse forming network) switched with an overvoltage air spark gap. This arrangement delivers 3/spl sim/5-nanosecond long pulses with sub-nanosecond rise time to the cuvette load. In order to minimize the spark gap distance, and thus the rise time, the Blumlein PFN is charged within 500 ns by a MOSFET-based high-voltage resonant charger.

Keywords

power MOSFET; pulse generators; pulsed power supplies; 500 ns; MOSFET-based high-voltage resonant charger; cuvette load; metal-oxide semiconductor field effect transistor; minipulser; overvoltage air spark gap; pulse generator; short pulse cell electroperturbation; spark gap distance; subnanosecond rise time; water dielectric Blumlein pulse forming network; Biomembranes; Cells (biology); Circuits; Dielectrics; Impedance; Power transmission lines; Pulse generation; Pulsed power supplies; Sparks; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Pulsed Power Conference, 2003. Digest of Technical Papers. PPC-2003. 14th IEEE International

Conference_Location

Dallas, TX, USA

Print_ISBN

0-7803-7915-2

Type

conf

DOI

10.1109/PPC.2003.1277966

Filename

1277966