Transition phenomena affecting the shape of pulses observed during individual cell flow through micropores

Author

Barbounaki, S. ; Vazouras, C.N. ; Kehli, A. ; Boynard, M. ; Koutsouris, D.

Author_Institution

Lab. of Biophys. Appl., Univ. Rene Descartes, Paris, France

Volume

6

fYear

1997

fDate

30 Oct-2 Nov 1997

Firstpage

2377

Abstract

An analytical model is proposed to study the variation of the current flowing through a micropore when a red blood cell (modelled as an insulating sphere) approaches the pore, in order to examine the rise and decrease parts of the current pulse obtained in Coulter-principle deformability measurements. A moment-method procedure is used to solve the problem for the electric current values, with special care devoted to avoiding singularities and ensuring fast convergence of the expressions for the final matrix elements. Numerical results are presented, which appear to imply that a smaller estimate than the total pulse length is appropriate for the cell transit time

Keywords

Galerkin method; Green´s function methods; bioelectric phenomena; blood flow measurement; capillarity; haemorheology; method of moments; physiological models; Coulter-principle deformability measurement; Galerkin scheme; Green´s functions; analytical model; current pulse; electric current values; fast convergence; individual cell flow; insulating sphere; microcirculatory parameter; micropores; moment-method procedure; red blood cell; shape of pulses; transition phenomena; Biomedical measurements; Current measurement; Dielectrics and electrical insulation; Filters; Pulse generation; Pulse measurements; Pulse shaping methods; Red blood cells; Rheology; Shape;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1094-687X

Print_ISBN

0-7803-4262-3

Type

conf

DOI

10.1109/IEMBS.1997.756796

Filename

756796