Correlation of genomics features with the date and party hub distinction: A view from three dimensional protein structures

The idea of the existence of date and party hubs in protein-protein interaction networks (PPI) has been influential since it was proposed in 2004. However, the validity of such a distinction remains a subject of debate. Based on the incorporation of the information extracted from known three-dimensional structures of protein interactions, we revisited the properties associated with date and party hubs previously identified. The correlation of genomic essentiality and gene coexpression with the date and party hubs were studied. The results suggested that the identification of date and party hubs based on their network connectivity and expression profiles with interaction partners may be incomplete. The number of interaction interfaces could play an important role in examining the topological properties associate with each protein included in PPI networks.