Label free piezoelectric DNA sensor array by selective immobilization via electrochemical method

Author

Kao, P. ; Allara, D. ; Tadigadapa, S.

Author_Institution

Dept. of Electr. Eng., Pennsylvania State Univ., University Park, PA, USA

fYear

2011

fDate

23-27 Jan. 2011

Firstpage

900

Lastpage

903

Abstract

An 8-pixel quartz crystal resonator array with a fundamental resonance frequency of 73 MHz has been designed and fabricated. We established a protocol for selectively functionalizing the surface of resonator array via electrochemical desorption. The creation of hydrophobic and hydrophilic surface with methyl terminated and carboxylate terminated alkanethiols is characterized by Fourier transform spectroscopy (FTIR) and contact angle measurements. QCMs functionalized with hydrophobic and hydrophilic terminations show a clearly distinguishable response to ionic (buffer) solution.

Keywords

DNA; Fourier transform spectra; biosensors; contact angle; crystal resonators; desorption; electrochemical analysis; electrochemical sensors; hydrophilicity; hydrophobicity; infrared spectra; microfabrication; molecular biophysics; sensor arrays; FTIR; Fourier transform spectroscopy; buffer solution; carboxylate terminated alkanethiols; contact angle measurements; electrochemical desorption; electrochemical method; frequency 73 MHz; hydrophilic surface; hydrophilic terminations; hydrophobic surface; hydrophobic terminations; ionic solution; label free piezoelectric DNA sensor array; methyl terminated alkanethiols; quartz crystal resonator array; resonance frequency; selective immobilization; Arrays; Biosensors; Crystals; Electrodes; Ethanol; Gold; Pixel;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems (MEMS), 2011 IEEE 24th International Conference on

Conference_Location

Cancun

ISSN

1084-6999

Print_ISBN

978-1-4244-9632-7

Type

conf

DOI

10.1109/MEMSYS.2011.5734571

Filename

5734571