• DocumentCode
    2771256
  • Title

    An algorithm for string edit distance allowing substring reversals

  • Author

    Arslan, Abdullah N.

  • Author_Institution
    Dept. of Comput. Sci., Vermont Univ., Burlington, VT
  • fYear
    2006
  • fDate
    16-18 Oct. 2006
  • Firstpage
    220
  • Lastpage
    226
  • Abstract
    The edit distance between given two strings X and Y is the minimum number of edit operations that transform X into Y. Ordinarily, string editing is based on character insert, delete, and substitute operations. It has been suggested that extending this model with block (substring) edits would be useful in applications such as DNA sequence comparison. In its general form, the resulting problem is NP-hard. However, there are efficient algorithms when string edits include only character, and block replacements. We introduce a new edit model which permits insertions, deletions, and substitutions at character level, and also reversals of substrings. We present an algorithm whose worst-case time complexity is O(n2m) where n=|X|lesm=|Y|, and we prove that the average running time of the algorithm is O(nm). Our experiments on randomly generated strings verify these results. The main contribution of this paper is that we present an algorithm to find all possible reversals using a generalized suffix tree, which is fast on average
  • Keywords
    DNA; biology computing; computational complexity; molecular biophysics; string matching; trees (mathematics); DNA sequence comparison; block replacements; block reversal; character delete; character insert; character substitute operations; generalized suffix tree; randomly generated strings; string edit distance; substring reversals; Bioinformatics; Biological system modeling; Biology computing; Computational modeling; Computer science; DNA; Genetic mutations; Genomics; Sequences; Sorting;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    BioInformatics and BioEngineering, 2006. BIBE 2006. Sixth IEEE Symposium on
  • Conference_Location
    Arlington, VA
  • Print_ISBN
    0-7695-2727-2
  • Type

    conf

  • DOI
    10.1109/BIBE.2006.253338
  • Filename
    4019663