Effect of sodium channel parameters on reentrant arrhythmia: A computational study

Untiring cardiac activity keeps human being to perform activities from birth to death. Cardiac dysfunction is associated with a variety of cardiovascular conditions that lead to heart failure. These cardiovascular diseases (CVD) are responsible for more than 5 million deaths each year. A major group of CVD involves disturbances in the normal cardiac rhythm (Cardiac Arrhythmias) due to failure in the coordination among contraction of cardiac muscles. Among several types of cardiac arrhythmias, ventricular reentrant arrhythmia is being more dangerous. Recent theoretical and experimental studies have stressed the importance of modeling of reentrant arrhythmia. This presentation discusses the ventricular reentrant arrhythmia using computational models of cardiac ventricular cell from cellular level to tissue level.