• DocumentCode
    2781051
  • Title

    A Urine 1H NMR based metabonomic approach to understand the host metabolic response towards Plasmodium vivax infection

  • Author

    Sengupta, Arjun ; Ghosh, Soumita ; Sonawat, Haripalsingh M. ; Basant, Angika ; Sharma, Shobhona ; Kshirsagar, N.A. ; Gogtay, N.

  • Author_Institution
    Dept. of Chem. Sci., Tata Inst. of Fundamental Res., Mumbai, India
  • fYear
    2010
  • fDate
    16-18 Dec. 2010
  • Firstpage
    172
  • Lastpage
    176
  • Abstract
    External stressors like parasites cause alteration in the metabolic pathways of the host. Monitoring the small molecular weight metabolites in the tissue or biofluid offer a convenient approach to understand these alterations. In this paper, we report a urine 1H NMR based metabonomic study to understand the alterations in the human host during the infection of the malarial parasite Plasmodium vivax. Our study reveals distinct metabolic changes during the disease. Some of them could be useful in order to understand the increasing severity of the P. vivax infection.
  • Keywords
    biochemistry; biomedical NMR; diseases; microorganisms; molecular biophysics; patient diagnosis; patient monitoring; proton magnetic resonance; Plasmodium vivax infection; biofluid; disease; external stressors; host metabolic response; malarial parasite; metabonomic approach; small molecular weight metabolites; tissue; urine 1H NMR; Analytical models; Diseases; Electron tubes; Hospitals; Microscopy; Monitoring; Nuclear magnetic resonance; Malaria; Metabolism; Metabonomics; NMR; Plasmodium vivax;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Systems in Medicine and Biology (ICSMB), 2010 International Conference on
  • Conference_Location
    Kharagpur
  • Print_ISBN
    978-1-61284-039-0
  • Type

    conf

  • DOI
    10.1109/ICSMB.2010.5735366
  • Filename
    5735366
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=2781051