Rapid prototyping of glass chip with micro-powder blasting using nano-particles dispersed polymer

We present a new rapid prototyping technique to produce a glass chip with high aspect ratio channel for micro total analysis system (μTAS). This technique consists of powder blasting technique and laser patterning of newly developed Au nano-particles dispersed polymer mask. The microchannel with maximum aspect ratio of 2.1 in a glass substrate was successfully realized without photolithography step. The proposed technique was applied to a glass chip for electrophoresis and its performance for DNA separation analysis was confirmed. Furthermore, the micro-powder blasting technique with elevated temperature of Au nano-particles dispersed polymer mask was proposed for the first time.