Noise reduction by feedback in gene regulation

Summary form only given. Transcription of gene information to mRNA is a chemical process in which only a very small amount of molecules take part. This inevitably causes large fluctuations of the number of transcribed proteins. It is considered that feedback from the generated molecules would reduce such fluctuations. In this presentation, we show that this hypothesis holds true through direct simulations of master equations and the so-called linear noise approximations. The results highlight the role of feedback in genome regulation.