Multiparameters monitoring for long term in-vivo characterization of electrode-tissues contacts

This paper concerns the design of an integrated circuit (IC) dedicated to monitor electrode-tissues contact (ETC). It is the main module of an implantable telemetry device. This device allows one to apply various principles of electrochemical system´s studies, such as cyclic voltammetry, electrochemical impedance spectroscopy, galvanostatic double pulse method, and thus, to measure the evolution of various parameters surrarounding the ETC: complex impedance, faradic resistance, double layer capacity, rheobase current and chronaxy time. The circuit has been designed and implemented with the CMOS 0.18 mum technology with an area of 2mm². The proposed technique and the IC functionalities were validated in our laboratory during in-vitro experimentations.