Modeling microelectrode sensors for cell-culture monitoring

It is proposed the use of a cell-microelectrode model for cell biometry applications. The model can be applied to cell size identification, cell count, and extended to cell growth and dosimetry protocols, by identifing the total area covered by cells. The work develops Analog Hardware Description Language (AHDL) codes for cell-microelectrode systems, considering the geometrical and technological parameters, enabling the possibility to simulate biological complex systems with convencional mixed-mode simulators as SpectreHDL. Experimental results are presented to calculate the cell number in growth and dosimetry experiments using AA8 cell line.