Applications of time-resolved fluorescence spectroscopy to atherosclerotic cardiovascular disease and brain tumors diagnosis

Author

Marcu, Laura ; Jo, Javier A. ; Fang, Qiyin ; Papaiannou, Thanassis

Author_Institution

Dept. of Surg., Cedars-Sinai Med. Center, Los Angeles, CA, USA

Volume

3

fYear

2005

fDate

22-27 May 2005

Firstpage

2227

Abstract

This paper presents the development of an apparatus and associated practical methodologies for time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) of tissues that account for clinical needs and overcome some of the barriers that have limited its implementations in clinical settings. These include rapid fluorescence data acquisition with high temporal resolution and sensitivity within a broad range of emission wavelengths; rapid data processing, analysis and display; and compact and portable instrumentation.

Keywords

bio-optics; brain; cancer; cardiovascular system; fluorescence; patient diagnosis; time resolved spectroscopy; tumours; atherosclerotic cardiovascular disease; brain tumors diagnosis; compact instrumentation; high temporal resolution; portable instrumentation; rapid data analysis; rapid data display; rapid data processing; rapid fluorescence data acquisition; time-resolved laser-induced fluorescence spectroscopy; tissues; Cardiovascular diseases; Fiber lasers; Fluorescence; Instruments; Neoplasms; Optical pulse generation; Pathology; Probes; Space vector pulse width modulation; Spectroscopy;

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics, 2005. (CLEO). Conference on

Print_ISBN

1-55752-795-4

Type

conf

DOI

10.1109/CLEO.2005.202425

Filename

1573491