Design of a Si Photonic Wire "Lab on a Chip" Arrayed Biosensor

Author

Zhang, Yaping

Author_Institution

Fac. of Eng., Univ. of Nottingham Ningbo, Ningbo, China

fYear

2012

fDate

21-23 May 2012

Firstpage

1

Lastpage

4

Abstract

This paper presents a design for a label free Si photonic wire "lab on a chip" arrayed biosensor with 8 sensing and 8 reference channels. It provides an advanced means for the label free detection of target molecules, for affinity binding analysis and for the time domain real-time monitoring and parallel detection of solutions, gases, or reactions near the sensing channel surface. The sensitivity of detection of the device is at the highest level among all the other methods, which is at least 10-100 times more sensitive than that of currently commercial available biosensor devices and instruments. The fabrication of the device is compatible with well-established semiconductor fabrication technologies. The device is able to be monolithically integrated with CMOS electronics, and combined with microfluidics.

Keywords

CMOS integrated circuits; bio-optics; bioMEMS; biosensors; elemental semiconductors; gas sensors; lab-on-a-chip; microfluidics; microsensors; molecular biophysics; monolithic integrated circuits; optical sensors; real-time systems; sensitivity; sensor arrays; silicon; time-domain analysis; Si; affinity binding analysis; commercial available biosensor devices; commercial available biosensor instruments; gas sensors; microfluidics; molecule label free detection; monolithically integrated CMOS electronics; parallel solution detection; reference channels; sensing channel surface; sensitivity; silicon photonic wire lab-on-a-chip arrayed biosensor; the time domain real-time monitoring; well-established semiconductor fabrication technologies; Biosensors; Optical interferometry; Optical sensors; Optical surface waves; Optical waveguides; Silicon;

fLanguage

English

Publisher

ieee

Conference_Titel

Photonics and Optoelectronics (SOPO), 2012 Symposium on

Conference_Location

Shanghai

ISSN

2156-8464

Print_ISBN

978-1-4577-0909-8

Type

conf

DOI

10.1109/SOPO.2012.6270970

Filename

6270970