Development of physiological simulation environment for hemodynamics of cardiovascular system

The purpose of this study is to provide a physiological simulation environment for modeling and diagnosing the cardiovascular system as part of circulatory system in the whole body. The circulatory system model aims to represent various changes and diseases quantitatively based on clinical measurements. In respect with some measurement or diagnosis levels, the circulatory system could be modeled into a target granularity of sizes, resolutions, or timescales. There are opposite advantages and shortcomings in the macro and micro models for physiological simulation. On the one hand, the macro model contains a wide range of physiological information for various organs, functions, and subsystems within the whole body, but it is impossible to be detailed into small time units for time-dependent variables. On the other hand, the micro model enables to analyze microscopic behavior only for a single subsystem, because the extra functions of the whole body are omitted. Therefore, the proposed physiological simulation method integrates macro circulatory and micro cardiovascular system models, so that long-term macroscopic body conditions and short-term microscopic blood flow could be concurrently simulated.