DocumentCode
3047703
Title
Influence of Formaldehyde on the Expression of Rab26 Gene in HEK293 Cell in Vitro
Author
Ying, Jiang ; Lifeng, Bao ; Kai, Wu ; Junlin, Yuan
Author_Institution
Coll. of Life Sci., Huazhong Normal Univ., Wuhan
fYear
2007
fDate
6-8 July 2007
Firstpage
211
Lastpage
214
Abstract
In this study HEK293 cell was treated with HCHO (ges 250 mu M) of different concentrations and Rab26 gene expression was examined by using RT-PCR method. The results showed that with the elevation of the concentrations of HCHO, the amount of DNA-protein crosslink (DPC) was significantly enhanced (P< 0.01). Meanwhile, accompanied with the elevation of DPC amount after HCHO treatment, the amount of replication and transcription of Rab26 was reduced as examined by PCR and RT-PCR method.
Keywords
DNA; biochemistry; genetics; organic compounds; proteins; toxicology; DNA-protein crosslink; HEK293 cell; RT-PCR method; Rah26 gene expression; diseases; formaldehyde; replication; toxicities; transcription; Bioinformatics; Biological cells; DNA; Fluorescence; Genetic mutations; Genomics; In vitro; Polymers; Proteins; RNA;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, 2007. ICBBE 2007. The 1st International Conference on
Conference_Location
Wuhan
Print_ISBN
1-4244-1120-3
Type
conf
DOI
10.1109/ICBBE.2007.57
Filename
4272541
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