DocumentCode
304791
Title
Automatic segmentation and modelling of two-dimensional electrophoresis gels
Author
Bettens, E. ; Scheunders, P. ; Sijbers, J. ; Van Dyck, D. ; Moens, L.
Author_Institution
Dept. of Phys., Antwerp Univ., Belgium
Volume
1
fYear
1996
fDate
16-19 Sep 1996
Firstpage
665
Abstract
An important issue in the analysis of two-dimensional electrophoresis images is the detection and quantification of protein spots. In this paper we describe a new robust technique to segment and model the different spots present in the gels. For the segmentation a watershed technique is applied. For the quantification of the spots, a new spot model is constructed, based on diffusion principles. Besides the advantage of having a physical interpretation, the model is demonstrated to be superior to the commonly used Gaussian models
Keywords
biological techniques; biology computing; electrophoresis; gels; image recognition; image segmentation; proteins; automatic segmentation; detection; diffusion; protein spots; quantification; robust technique; spot model; two-dimensional electrophoresis gels; Diffusion processes; Electrokinetics; Image analysis; Image processing; Image segmentation; Pattern analysis; Pattern recognition; Physics; Proteins; Robustness;
fLanguage
English
Publisher
ieee
Conference_Titel
Image Processing, 1996. Proceedings., International Conference on
Conference_Location
Lausanne
Print_ISBN
0-7803-3259-8
Type
conf
DOI
10.1109/ICIP.1996.560965
Filename
560965
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