3D protein structure determination by THz spectroscopy and molecular modelling: case study on bovine serum albumin

Author

Mernea, M. ; Leca, A. ; Calborean, O. ; Dinca, M.P. ; Dascalu, T. ; Mihailescu, D.

Author_Institution

Fac. of Biol., Univ. of Bucharest, Bucharest, Romania

fYear

2009

fDate

Nov. 3 2009-Oct. 6 2009

Firstpage

49

Lastpage

50

Abstract

THz spectroscopy is a very powerful tool in investigating the vibrational modes and conformational transitions of biomolecules. Here we have used THz spectroscopy to study the vibrational spectrum of bovine serum albumin, a protein whose 3D structure is yet unknown. Experimental data were fitted with theoretical spectra obtained by normal modes analysis of BSA structures generated by homology modeling.

Keywords

molecular biophysics; proteins; submillimetre wave spectroscopy; 3D protein structure determination; bovine serum albumin; molecular modelling; terahertz spectroscopy; vibrational modes; Analytical models; Biological system modeling; Bovine; Molecular biophysics; Physics; Plasma simulation; Proteins; Root mean square; Simulated annealing; Spectroscopy;

fLanguage

English

Publisher

ieee

Conference_Titel

Terahertz and Mid Infrared Radiation: Basic Research and Practical Applications, 2009. TERA-MIR 2009. International Workshop

Conference_Location

Turunc-Marmaris

Print_ISBN

978-1-4244-3848-8

Electronic_ISBN

98-1-4244-3849-5

Type

conf

DOI

10.1109/TERAMIR.2009.5379635

Filename

5379635